Extended Data Figure 7: Dynamic expression patterns and network of transcription factors during HSC formation. | Nature

Extended Data Figure 7: Dynamic expression patterns and network of transcription factors during HSC formation.

From: Tracing haematopoietic stem cell formation at single-cell resolution

Extended Data Figure 7

a, Heat map of genes showing different expression patterns in ECs and pre-HSCs. Note four distinct expression patterns as highly expressed in pre-HSCs (I), highly expressed in T2 pre-HSCs (II), highly expressed in T1 pre-HSCs (III), and highly expressed in ECs (IV). b, Heat map of genes showing different expression patterns in pre-HSCs (T1 and T2) and mature HSCs (E12 and E14). Note five distinct expression patterns as highly expressed in T1 pre-HSCs (I), highly expressed in E14 HSCs (II), highly expressed in pre-HSCs (III), and heterogeneous in all cell types (IV), and highly expressed in T2 pre-HSCs (V). c, Heat map of expression dynamics of transcription factors highly related to the above patterns in these single cells. d, Network view of transcription factors (TFs) related to different expression patterns determined in Fig. 5b. Transcription factors were arranged using circle layout in Cytoscape. A deeper background colour of the gene names indicates higher correlations of transcription factors to that expression pattern. e, f, Bar plot of expression dynamics of selected transcription factors in single cells showing different expression patterns in distinct cell types.

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