Extended Data Figure 1: Cancer cell–astrocyte interactions.
From: Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
a, Representative images and quantification of Cx43 immunostaining in matched primary and brain metastatic samples from patients with NSCLC. Scale bar, 100 μm (n = 8 patients). b, Cancer cells used in this study. The following references are cited in the table: 3, 6, 12, 13, 50 and 51. c, Astrocyte co-culture protects cancer cells. As illustrated in schema (left), cleaved caspase 3+ GFP+ apoptotic BrM cells were quantified by flow cytometery after sFasL addition or chemo-treatments (3 independent experiments). d, Flow cytometric quantification of dye transfer from astrocytes to MDA231-BrM2 cells over time (3 independent experiments).
