Extended Data Figure 7: Aberrant transcription affecting PD-L1 3′-UTR and associated genomic alterations identified in multiple cancers.
From: Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
a, Genomic structure of the rearranged PD-L1 locus and transcription in FA-A4XK-01 (DLBC), BP-4983-01 (KIRC), L5-L4OE-01 (ESCA), and F5-6814-01 (READ), showing loss of PD-L1 3′-UTR transcription and fusion transcripts between PD-L1 and intronic or intergenic segments. Breakpoints (blue dotted lines) are shown with accompanying copy number alterations. Del, deletion. b, PD-L1 DNA copy number versus JAK2 mRNA expression across 48 DLBC (left), 415 STAD (middle), and 43 ATL (right) samples. SV(+) samples (red) and those with 9p24.1 copy number gains involving both JAK2 and PD-L1 genes (orange) are indicated. P values for the effects of PD-L1 SVs and copy number on JAK2 expression (GLM) are shown. c, Genomic structure of the rearranged PD-L1 locus and transcription in two cases with viral integrations around the PD-L1 gene; a STAD case (FP-7998-01) with an EBV integration (top) and an HNSC case (CV-5443-01), showing HPV16 integration, which was described previously19, and premature termination of PD-L1 transcripts within intron 4 (bottom).
