Extended Data Figure 9: Model of BCC initiation.
From: Defining the clonal dynamics leading to mouse skin tumour initiation
Activation of SmoM2 in SCs leads to the generation of BCC owing to an increase in cell proliferation and resistance to apoptosis. However, activation of p53 in SmoM2-expressing CPs restricts the progression of dysplastic clones to BCC by promoting apoptosis and cell-cycle arrest. Deletion of p53 in CPs allows them to progress into BCC.
