Extended Data Figure 2: Evolution of K14-CreER/Rosa-YFP and Inv-CreER/Rosa-YFP clones in scale and interscale regions.
From: Defining the clonal dynamics leading to mouse skin tumour initiation
a, Whole-mount immunostaining for YFP/K31 in K14-CreER/Rosa-YFP mice and Inv-CreER/Rosa-YFP mice upon tamoxifen administration. b, Scheme representing the area of tail epidermis (area comprised by 6 groups of triplets of hair follicles, highlighted in black) that is used to quantify the clone number and persistence. c, Distribution of K14-CreER/Rosa-YFP and Inv-CreER/Rosa-YFP total clone sizes as measured by total cell content of surviving clones, imaged by confocal microscopy on whole-mount tail epidermis from 1 to 24 weeks after tamoxifen administration. The number of analysed clones is indicated for each time point. Hoechst nuclear staining is represented in blue; scale bars, 100 μm. Histograms and error bars represent the mean and the standard error of the mean (s.e.m.).
