Extended Data Figure 2: Time-dependent changes in body content and metabolic measures between non-ablated and DBB-ablated mice.
From: A cholinergic basal forebrain feeding circuit modulates appetite suppression
a, Oxygen consumption, represented as VO2, at various stages post DBB-ablation. Data are represented as mean ± s.e.m. *P < 0.05 by two-sided, unpaired Student’s t-test. b, c, Average total lean mass (b) or body fat (c) content at various stages post DBB-ablation. Data are represented as mean ± s.e.m. *P < 0.05 by two-sided, unpaired Student’s t-test. d–f, Blood cholesterol (d), leptin (e), insulin (f), and blood glucose concentration (g) at various stages post DBB-ablation. Data are represented as mean ± s.e.m. *P < 0.05 by two-sided, unpaired Student’s t-test. h, i, Representative non-ablated (h) or DBB-ablated (i) animals (n = 3 mice) dissected to show abdominal fat pads and enlarged fatty livers. j, k, Representative haematoxylin and eosin (H&E) stains showing fat deposition of the liver in non-ablated (j) or DBB-ablated (k) animals. Scale bar, 100 μm.
