Extended Data Figure 4: hM4D-mediated inhibition of the cholinergic DBB increases food intake.
From: A cholinergic basal forebrain feeding circuit modulates appetite suppression
a, Whole-cell electrophysiological recordings from a representative cholinergic neuron expressing the hM4D inhibitory DREADD receptor before (top) and after (bottom) CNO treatment. b, Total two-hour food intake after an overnight fast (n = 11 mice). ‘Saline’ and ‘CNO’ groups represent separate trials of the same animals in the absence or presence of CNO, respectively. Data are represented as mean ± s.e.m. *P < 0.05 by two-sided, paired Student’s t-test.
