Extended Data Figure 9: Modelling the xOoA components with FineSTRUCTURE.
From: Genomic analyses inform on migration events during the peopling of Eurasia
a, Joint distribution of haplotype lengths and derived allele count, showing the median position of each cluster and all haplotypes assigned to it in the maximum a posteriori (MAP) estimate. Note that although a different proportion of points is assigned to each in the MAP, the total posterior is very close to 1/K for all. The dashed lines show a constant mutation rate. Haplotypes are ordered by mutation rate from low to high. b, Residual distribution comparison between the two-component mixture using EUR.AFR and EUR.PNG (left), and the three-component mixture including xOoA (using the same colour scale) (right). The root mean square error (RMSE) residuals without xOoA are larger (RMSE = 0.0055 compared to RMSE = 0.0018) but more importantly, they are also structured. c, Assuming a mutational clock and a correct assignment of haplotypes, we can estimate the relative age of the splits from the number of derived alleles observed on the haplotypes. This leads to an estimate of 1.5 times older for xOoA compared to the Eurasian–Africa split.
