Extended Data Figure 8: Alteration of In-PDGFRα levels in vivo modulates muscle fibrosis.
From: Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis
a, b, Fibro–adipose index of muscles treated with pA-VMOs (n = 9) (a) or the 5′ss VMO (control: n = 9, 5′ss-VMO: n = 10) (b). c, Representative images of Gomori-trichrome staining and quantification of fibrosis of BaCl2-treated muscles from aged mice treated with the control VMO (n = 10), pA-VMOs (n = 9) or the 5′ss-VMO (n = 10). For a–c, n represents biological replicates consisting of tibialis anterior muscles isolated from individual mice. Scale bars, 100 μm. Error bars represent s.e.m. *P < 0.05; **P < 0.01; unpaired Student’s t test.
