Extended Data Figure 1: Molecular function of 810 mutant mouse lines screened and phenotypic characterization members of the interferon regulatory factor (Irf) family.

a, Molecular function Gene Ontology annotation of the 810 mutant mouse lines screened as detailed in Methods. b, Experimental metastasis assay using B16-F10 cells in Irf1^tm1a/tm1a, Irf5^tm1e/tm1e, Irf7^tm1a/tm1a and concurrent control female mice. Shown are representative data from two (Irf5), four (Irf1) or six (Irf7) independent experiments. Symbols represent individual mice with a horizontal bar at the mean. P values are from a Mann–Whitney test. c–f, Representative photographs showing B16-F10 metastatic colonies on the (c) lungs of +/+ and Irf1^tm1a/tm1a mice and (d–f) the presence of extra-pulmonary metastases in Irf1^tm1a/tm1a mice (tissues from three mice shown).