Extended Data Figure 2: Alternative analysis of ecDNA presence according to varying criteria, stratified by sample type.
From: Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Samples with a minimum number of ecDNA elements per 10 cells in metaphase in average shown in x axis are classified ecDNA positive, and their fraction is displayed on the y axis. The vertical line at x = 4 shows that for a minimum of 4 ecDNA elements per 10 cells in metaphase on average, 0% of normal, 10% of immortalized, 46% of tumour cell line and 89% of PDX samples are classified as ecDNA positive.
