The enzyme S6K1 phosphorylates the enzyme glutamyl-prolyl tRNA synthetase to modulate metabolic activity and lifespan, revealing an atypical role for this synthetase as a target of a key metabolic signalling pathway. See Letter p.357
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Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
Experimental & Molecular Medicine Open Access 02 October 2023
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Selman, C., Withers, D. An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017). https://doi.org/10.1038/nature21500
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DOI: https://doi.org/10.1038/nature21500
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Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
Experimental & Molecular Medicine (2023)
Har Katcher
There is a connection between fat metabolism, reproduction and lifespan noted in many species, such that long-lived animals tend to store more fat and have a lower reproductive rates. Now nothing was said about reproduction of these S999A mice, but the fact that they store less fat is contrary to what is expected of a long-lived animal. I think it's time to stop kicking the can down the road and find out what fat metabolism has to do with longevity. Here we have a mutant said to be long-lived because it stores less fat, while other long-lived mutants seem to have increased longevity because they store more fat.