Extended Data Figure 7: The MRCA cell of adult blood cells is the MRCA cell of all somatic cells (or the fertilized egg).
From: Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
See Supplementary Discussion 4. Using the expected proportion of mutations shared with cancer (Extended Data Fig. 6), we estimated the timing when the MRCA cell of adult blood cells is formed. The four orange boxes show the expected proportions from four scenarios, when there are 0, 1, 2 and 3 cell generation gaps between the MRCA cells. The observed proportion (26%; green horizontal line) in this study is closest to the expectation from the model of 0 cell generation gap. Error bars are interquartile range × 2 (from the simulation study).
