Extended Data Figure 8: Mutagenesis of the AT2R ligand-binding pocket.
From: Structural basis for selectivity and diversity in angiotensin II receptors
a, Ligand-binding pocket from the AT2R–compound 1 crystal structure. b, Ligand-binding pocket from the AT1R–olmesartan crystal structure. c, Schematics of interactions between compound 1 and AT2R residues. d, Schematics of interactions between olmesartan and AT1R residues. In all panels, residues are coloured according to their effect on affinity: more than 100-fold decrease in affinity (orange); 5–100-fold decrease in affinity (yellow); and less than 5-fold decrease in affinity (grey). e, Effects of single residue mutations in the AT2R ligand-binding pocket on the ligand binding affinities. Values represent mean ± s.d. with the number of experiments shown in parenthesis.
