Extended Data Figure 6: Evaluating multiple rounds of Zika virus hybrid capture.

Genome assembly statistics of samples before hybrid capture (grey), and after one (blue) or two (red) rounds of hybrid capture. Nine individual libraries (eight unique samples) were sequenced all three ways, had more than one million raw reads in each method, and generated at least one passing assembly. Raw reads from each method were downsampled to the same number of raw reads (8.5 million) before genomes were assembled. a, Per cent of the genome identified, as measured by number of unambiguous bases. b, Median sequencing depth of ZIKV genomes, taken over the assembled regions.