Extended Data Figure 3: Analysis of the CD11cCre;Braf V600E mouse model.
From: A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
a, Kaplan–Meier survival curve of Braf VE (n = 16) and Braf WT (n = 66) controls. Log-rank (Mantel–Cox) test. b, Representative photographs of lung and spleen from Braf VE mice at time of death with representative Braf WT control organs. c, d, Haematoxylin and eosin staining of lung tissue from Braf VE and littermate controls. e, CD68 immunohistochemistry of Braf VE lung tissue. f, Haematoxylin and eosin staining of liver tissue from Braf VE and littermate controls with magnified image of granuloma in the Braf VE liver. g, Haematoxylin and eosin staining of bone marrow (BM) of Braf VE and littermate controls with CD68 immunohistochemistry of Braf VE mouse tissue. All images for b–g are representative of n = 5 per genotype.
