Extended Data Figure 7: Mfsd2b KO mice had mild reduction of circulatory lymphocytes and were more susceptible to PAF-induced anaphylactic shock.
From: Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets
a, b, Circulatory numbers of T and B cells from 2-month-old male mice, respectively (11 mice per genotype, 2 experiments). c, Response of 3-month-old male WT and KO mice to the treatment of FTY720, a lymphopenia drug (nine WT and eight KO, two experiments). d, Evans blue extravasation examination of WT and KO mice. There was no significant Evans blue extravasation seen in KO mice. e, Survival curve of 2- to 3-month-old male WT and KO mice to a treatment of PAF (20 μg/kg (body weight)). Mfsd2b KO mice were more significantly sensitive to PAF treatment (11 WT and 9 KO, 2 experiments). P values were calculated using two-tailed unpaired t-tests for a–c and a Mantel–Cox test for e. Data are mean and s.e.m.
