Extended Data Figure 5: TGFβ superfamily signalling overcomes SKI–SMAD4 complex-mediated suppression of RORγt expression in activated T cells to enable TH17 cell differentiation.
From: Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation
a, RORγt expression is potentiated by IL-6–STAT3 signalling but restrained by the histone deacetylase activity-containing SKI–SMAD4 complex that associates with and deacetylates the Rorc locus. b, Additional TGFβ or activin signalling triggers SKI degradation. The disruption of SKI–SMAD4 complex dissociates histone deacetylase activity from the Rorc locus and enables RORγt expression and TH17 cell differentiation.
