Extended Data Figure 8: Recurrent CNVs and structural variations.
From: The landscape of genomic alterations across childhood cancers
a, Genome-wide copy-number profiles normalized for tumour ploidy (n = 516). Cancer types are sorted by genome instability (Fig. 5a). Regions or genes with significant CNVs are indicated (blue, deleted; red, gained or amplified) (Fig. 5b). b, Relative copy-number status (normalized for tumour ploidy to baseline 1) for regions with significant copy-number changes (top, gains or amplifications; bottom, deletions) in n = 516 tumours. Thresholds (amplified: ≥1.4, deleted: ≤0.6) are based on the overall copy-number distribution indicated on the right. c, Genes affected by breakpoints from structural variants and additional genes associated with clustered breakpoints (in square brackets). Samples are divided into sub-cohorts of tumours with (bottom, n = 73) and without (top, n = 455) chromothripsis. Genes overlapping (direct overlap or within ±200 kb) with genes with significant copy-number changes from a (blue, deletions; red, amplifications).
