Extended Data Figure 10: Genetic events define mutation classes.
From: The landscape of genomic alterations across childhood cancers
a, Genes significantly or recurrently affected by mutations, amplification, deletions, and gene-disrupting structural variants (likely functional events, LFEs). Copy-number and structural variations are summarized as SC-class in contrast to mutations (SNVs or indels) as M-class. b, Number of SC-class (x-axis) and M-class (y-axis) alterations per tumour. c, Proportion of events from M-class and SC-class within each tumour. Tumours with more than 50% (mixed) or 100% (unique) events from one category are considered to be members of the associated class; tumours with equal contributions from both categories are ‘ambiguous’, and tumours without an LFE are assigned class ‘none’ (not shown). Colours indicate germline mutations per tumour. d, Fraction of tumours assigned to different classes per cancer type.
