Figure 3: Germline mutations in cancer predisposition genes.
From: The landscape of genomic alterations across childhood cancers
a, Frequency of patients with a pathogenic germline mutation per cancer type (n = 914 tumours). b, Mutated genes sorted by number of affected samples (del, copy-number alterations; others, SNVs/indels). c, Cellular processes associated with cancer predisposition genes. d, Frequency of germline mutations adjusted for incidence and estimated total proportion of childhood cancers likely to be linked to hereditary predisposition.
