Extended Data Figure 2: Mutational signatures in paediatric cancer types.
From: The landscape of genomic alterations across childhood cancers
a, Summarized contribution of signatures to mutational profiles per cancer type (proportion of mutations per signature and cancer type). Signatures with contributions of ≥5% in at least one cancer type are shown. The colour intensity reflects the relative activity of each signature per cancer type. b, Correlation of signature 1 with patient age per cancer type in this paediatric pan-cancer cohort (left, n = 503) compared to results from a global pan-cancer study on 30 cancer types (n = 7,042)15. c, Relative contributions of mutational signatures to somatic mutations per individual tumour, clustered within cancer types (n = 503). d, Correlation of signatures 3, 8, and 13 (somatic mutations) with genome instability (structural variants) per cancer type. e, Substitution type probabilities in trinucleotide context for the newly discovered mutational signature P1; contribution of signature P1 per tumour (n = 503); correlation of signature P1 with multiple nucleotide variants (MNVs); activity of signature P1 in ATRT subgroups (Wilcoxon rank-sum test, confidence interval 0.95). b–d, Spearman’s correlation, confidence interval 0.95.
