Extended Data Figure 3: Association of mutational signatures with genomic instability.
From: The landscape of genomic alterations across childhood cancers
a, Correlation of signatures with the number of structural variants across all tumours and selected cancer types (Spearman’s correlation, confidence interval 0.95). b, Association of signatures with chromothripsis across all tumours and within selected cancer types. TP53 mutation status (germline/somatic) is highlighted (Kolmogorov–Smirnov test, confidence interval 0.95, range of whiskers: 1.5 × interquartile range). c, Association of signatures with TP53 mutation status (germline/somatic/none) across all tumours and within selected cancer types (ANOVA and post hoc Tukey’s test, confidence interval 0.95, quartiles, range of whiskers: 1.5 × interquartile range). a–c, Cross-cohort n = 503, cancer types see Supplementary Tables 1, 4.
