Table 1 Recent patent applications in pharmacogenomics
Patent number | Description | Assignee | Inventor | Priority application date | Publication date |
|---|---|---|---|---|---|
WO 2010115154, US 20100273219 | A method of amplifying target nucleic acids in samples involving preparing an amplification mixture of forward and reverse primers comprising the target-specific portion and a barcode primer, comprising nucleotides, and subjecting the mixture to amplification. | Fluidigm (S. San Francisco, CA, USA) | Anderson M, Chen P, Kaper F, May A, Wang J | 4/2/2009 | 10/7/2010, 10/28/2010 |
US 20080038810, US 7816121 | A droplet microactuator comprising a substrate with electrodes for conducting droplet operations and temperature control elements arranged near the electrodes to transport nucleic acid droplets on electrodes; useful for nucleic acid amplification. | Paik PY, Pamula VK, Pollack MG, Duke University (Durham, NC, USA), Advanced Liquid Logic (Research Triangle Park, NC, USA) | Paik PY, Pamula VK, Pollack MG | 4/18/2006 | 2/14/2008, 10/19/2010 |
WO 2010115044 | A method for depleting a nucleic acid sample of nontarget nucleic acids involving denaturing the sample nucleic acids in a reaction mixture, contacting the denatured nucleic acids with at least one target-specific primer pair under suitable annealing conditions, conducting a first cycle of extension of any annealed target-specific primer pairs and conducting nuclease digestion of single-stranded nucleic acid sequences in the reaction mixture. | Fluidigm (S. San Francisco, CA, USA) | Zimmermann BG | 4/2/2009 | 10/7/2010 |
US 20100210025 | A system comprising assigning modules to a genome, assigning a value or weight to a module for a given profile, analyzing a genomic sequence to identify modules and assigning a profile to the sequence; useful, e.g., for profiling a genomic sequence. | Victor Chang Cardiac Research Institute (Darlinghurst, Australia) | George R, Wouters M | 8/15/2006 | 8/19/2010 |
WO 2008144345, EP 2145021 | A method of predicting the likelihood of atherapeutic response to insulin growth factor-1 receptor (IGF1R) modulator as a cancer treatment, comprising measuring levels of biomarker genes or proteins before and after exposing sample to IGF1R modulator. | Bristol-Myers Squibb (Princeton, NJ, USA) | Attar RM, Carboni JM, Chen J, Dongre AR, Gottardis MM, Hafezi R, Han X, Huang F, Hurlburt W, Robinson DM, Wittenberg GM | 5/17/2007 | 11/27/2008, 7/22/2010 |
US 20100178655, WO 2010083250 | Genotyping a single cell, comprising pre-amplifying an amplified genome to produce a pre-amplification reaction mixture comprising amplicons specific for target nucleic acids, and amplifying and detecting the amplicons. | Fluidigm (S. San Francisco, CA, USA) | Hamilton A, Lin M, Mir A, Pieprzyk M | 1/13/2009 | 7/15/2010, 7/22/2010 |
WO 2010075570 | A computer-accessible medium used forassembling at least one haplotype sequence or genotype sequence of at least one genome, with stored computer-executable instructions. | New York University (New York) | Mishra B, Narzisi G | 12/24/2008 | 7/1/2010 |
WO 2010048497 | A method of diagnosing predisposition to, orprogression of, Alzheimer's disease, comprising determining a genetic profile comprising at least one marker in a specified candidate region and correlating the genetic profile with a reference profile. | Genizon Biosciences (St. Laurent, Quebec, Canada), TechnoSynapse (Blainville, Quebec, Canada) | Belouchi A, Croteau P, Debrus S, Kebache S, Keith T, Little RD, Paquin B, Poirier J, Raelson JV, Segal J, van Eerdewegh P | 10/24/2008 | 4/29/2010 |
KR 2010011719 | A single-nucleotide polymorphism provided forcalretinin gene, retinoic acid receptor beta gene and pre-B-cell leukemia transcription factor 1 gene; for use in biochips for predicting the riskof obesity. | Jeong J | Gang S, Jeong J, Jeong M, Kim S | 7/25/2008 | 2/3/2010 |
JP 4403376 | A unit for detecting interaction betweensubstances (e.g., hybridization) that has areaction region, water-absorptive gel in the reaction region, an electrode and water-holding portion; useful in a substrate for bioassays for analyzing mutations of genes. | Sony (Tokyo) | Mamine T, Sakamoto Y, Segawa Y, Yuo K | 10/9/2003 | 1/27/2010 |
US 20090117583 | A new epidermal growth factor–like variant inskin (ELVIS)-2 polypeptide; useful for screening assays, detection assays, predictive medicine and methods of treatment. | Busfield SJ, Gearing DP,Millennium Pharmaceuticals (Cambridge, MA, USA) | Busfield SJ, Gearing DP | 11/19/1998 | 5/7/2009 |
