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The special case of gene therapy pricing

Gene therapy companies that pursue high, one-time payments for their products risk a backlash from payors. A better solution may lie in a pay-for-performance model.

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References

  1. Wilson, J.M. Genet. Eng. News 33, 62 (2013).

    Article  Google Scholar 

  2. Kohn, D.B., Pai, S.Y. & Sadelain, M. Biol. Blood Marrow Transplant. 19, S64–S69 (2013).

    Article  CAS  Google Scholar 

  3. Xiao, P.J., Lentz, T.B. & Samulski, R.J. Ther. Deliv. 3, 835–856 (2012).

    Article  CAS  Google Scholar 

  4. Maguire, A.M. et al. N. Engl. J. Med. 358, 2240–2248 (2008).

    Article  CAS  Google Scholar 

  5. Nathwani, A.C. et al. N. Engl. J. Med. 365, 2357–2365 (2011).

    Article  CAS  Google Scholar 

  6. Buchlis, G. et al. Blood 119, 3038–3041 (2012).

    Article  CAS  Google Scholar 

  7. Bryant, L.M. et al. Hum. Gene Ther. Clin. Dev. 24, 55–64 (2013).

    Article  CAS  Google Scholar 

  8. Anonymous. Delivering gene therapy to patients. Presented at the Jefferies 2014 Global Healthcare Conference, June 2–5, 2014, New York.

  9. Kesselheim, A.S. Milbank Q. 89, 450–502 (2011).

    Article  Google Scholar 

  10. Nathan, D.G. & Orkin, S.H. Genome Med. 1, 114 (2009).

    Article  Google Scholar 

  11. Berndt, E.R. & Hurvitz, J.A. Health Aff. (Millwood) 24, 653–665 (2005).

    Article  Google Scholar 

  12. Kremer, M. in Innovation Policy and the Economy (eds. Jaffe, A., Lerner, J. & Stern, S.) (MIT Press, Boston, 2001).

    Google Scholar 

  13. National Library of Medicine. Genetics Home Reference (National Library of Medicine, 2014).

  14. Brennan T. & Shrank W. J. Am. Med. Assoc. 312, 593–594 (2014).

    Article  CAS  Google Scholar 

  15. Bordonaro, G. Hartfordbusiness.com, vol. 2014 Cigna, Merck ink pay-for-performance deal. (The Hartford Business Journal, 2009). <http://www.hartfordbusiness.com/article/20090525/PRINTEDITION/305259968/cigna-merck-ink-pay-for-performance-deal>

  16. Gostin, L.O., Hyman, D., Jacobson, P.D. & Studdert, D. Law and the Health System: Casebook Series (Foundation Press, 2014).

    Google Scholar 

Download references

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Correspondence to Troyen A Brennan.

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Competing interests

J.M.W. is an advisor to and a founder of ReGenX Biosciences and Dimension Therapeutics; he also holds equity in and receives a grant from these companies. In addition, he is an inventor on patents licensed to various biopharmaceutical companies, including affiliates of ReGenX Holdings, and consults on an ad hoc basis for several biopharmaceutical companies. He is an inventor on the vector used in the Glybera product. T.A.B. is employed by and holds stock in CVS Caremark.

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Brennan, T., Wilson, J. The special case of gene therapy pricing. Nat Biotechnol 32, 874–876 (2014). https://doi.org/10.1038/nbt.3003

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