Table 1 Recent patent applications in three-dimensional cell culture
From: Recent patent applications in three-dimensional cell culture
Patent number | Description | Assignee | Inventor | Priority application date | Publication date |
|---|---|---|---|---|---|
US8828679B2 | A method for detecting a biological signal of a three-dimensional cell culture construct, including: providing a three-dimensional cell culture construct that contains at least two cell layers laminated to each other and a sensor particle capable of detecting a biological signal and observing the sensor particle optically. | Japan Science and Technology Agency (Saitama, Japan), Okano K, Akashi M, Matsusaki M | Matsusaki M, Akashi M, Okano K | 11/11/2008 | 9/9/2014 |
US20140206022A1 | A method of culturing a three-dimensional matrix comprising (i) a test matrix polymer and a population of cells in a nutrient medium, using an apparatus where the three-dimensional matrix comprises top and bottom surfaces, and the apparatus is configured to allow contact of the nutrient medium on the top surface and bottom surface of the three-dimensional matrix and (ii) assaying the population of cells for differentiation, where detection of differentiation is indicative of the test matrix polymer stimulating differentiation of a population of cells. | Allergan (Irvine, CA, USA) | Nuti GM, Verardo MR, Messina DJ | 12/17/2012 | 7/24/2014 |
US20140106395A1 | A hanging droplet plate that has a predetermined number of droplet compartments for receiving a droplet of liquid. A circumferential microfluidic wetting barrier is arranged to surround a respective cavity that prevents spreading of a droplet beyond the microfluidic wetting barrier. One additional circumferential microfluidic wetting barrier is arranged to surround circumferential microfluidic wetting barrier. A wettable area is arranged between two adjacent microfluidic wetting barriers. | Fattinger C, Iaiza P, Kissling T, Voegelin D, Zumstein T, Mcginnis C | Fattinger C, Iaiza P, Kissling T, Voegelin D, Zumstein T, Mcginnis C | 3/3/2011 | 4/17/2014 |
US20140087440A1 | A system for cultivating three-dimensional biological cells, comprising a diamagnet, an upper lifter magnet, and a culture chamber containing a culture medium and several bioattractive magnetized core particles, where the culture chamber is positioned relative to the diamagnet and upper lifter magnet to facilitate levitation of the magnetized core particles. | University of South Florida (Tampa, FL, USA), Becker JL, Coffin SB | Becker JL, Coffin SB | 6/30/2003 | 3/27/2014 |
US8633022B2 | Hydrogelating agents and hydrogels having novel chemical structures and composition. The hydrogel has an oligo- or poly(ethylene glycol) moiety, which is known to be biocompatible, and can be used in three-dimensional cell culture, separation/purification of cells and proteins, and controlled release of, for example, a proteinaceous pharmaceutical product. | The Ritsumeikan Trust (Kyoto, Japan), Asahi Kasei Kabushiki Kaisha (Osaka, Japan), Tamiaki H, Ogawa K, Toma K | Tamiaki H, Ogawa K, Toma K | 2/24/2009 | 1/21/2014 |
US8603806B2 | A cell culture apparatus comprising vessels formed of a material that is useful in radiation emitting, light transmission, fluorometric and/or colorimetric assays; and a cell support structure containing a scaffold having porosity to permit the transmission of radiant energy through it, and to facilitate three-dimensional cell growth. | The Ohio State University Research Foundation (Columbus, OH, USA), Yang S-T, Zhang X, Wen Y | Yang S-T, Zhang X, Wen Y | 11/2/2005 | 12/10/2013 |
US8551771B2 | A gel molding apparatus with a vessel that has solution chambers, comprising a lid plate, columns that project from a top surface of the lid plate, and a perforated plate having through-holes. | Chung Gung University (Taoyuan,Taiwan), Wu M-H, Tsai W-C | Wu M-H, Tsai W-C | 4/24/2009 | 10/8/2013 |
US8463418B2 | Methods for fabricating a porous three-dimensional cell culture construct for biomedical applications. The system has modeling software for transforming a virtual design into virtual cross-sections. | 3D BioTek (Hillsborough, NJ, USA), Liu Q, Lau WK | Liu Q, Lau WK | 8/22/2007 | 6/11/2013 |
US8450105B2 | A method of preparation of a mechanically reversible gel involving combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel's biocompatibility and convenience of use facilitates three-dimensional cell culture and fundamental studies of cell behavior in a more biologically relevant environment. | Agency for Science Technology and Research (Connexis, Singapore), Ying JY, Pek S, Wan ACA | Ying JY, Pek S, Wan ACA | 5/4/2006 | 5/28/2013 |
