Supplementary Figure 12: Characterization of BKSM-iNSCs
From: Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage
(A) Morphology of a BKSM-iNSC colony generated from Sox2-GFP MEFs (upper panel) and Sox2-GFP reporter expression (lower panel). (B) Scatter plot display of global microarray data of indicated samples, showing low linear regression coefficient (R2) of global gene expression between MEFs and BKSM-iNSCs and high R2 between BKSM-iNSCs and brain-derived NSCs. (C) Functional annotation of upregulated genes (2-fold or more) in BKSM-iNSCs vs. MEFs based on microarray data; top categories are shown together with the number of genes and Benjamini-Hochberg-corrected P-values.
