Figure 1: The NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge overview.
From: Prediction of human population responses to toxic compounds by a collaborative competition
The cytotoxicity data used in the challenge consist of the EC10 data generated for 884 lymphoblastoid cell line in response to 156 common environmental compounds. Participants were provided with a training set of cytotoxicity data for 620 cell lines and 106 compounds along with genotype data for all cell lines, RNA-seq data for 337 cell lines and chemical attributes for all compounds. The challenge was divided into two independent subchallenges: in subchallenge 1, participants were asked to predict EC10 values for a separate test set of 264 cell lines in response to the 106 compounds (only 91 toxic compounds were used for final scoring); in subchallenge 2, they were asked to predict population parameters (in terms of median EC10 values and 5th (q05) to 95th (q95) interquantile distance) for a separate test set of 50 compounds.
