Supplementary Figure 11: Relative abundances of 14 genera exhibiting significant differences.

The bacterial genera whose relative abundances are above 1% in any sample were used in a Wilcoxon test in relation to (a) provider (b) housing laboratory (c) strain (d) diet and (e) gender. See supplementary table S1. The test results were adjusted for FDR. “***”indicates p-value ≤ 0.001, “**”indicates p-value ≤ 0.01, “*”indicates p-value ≤ 0.05, “NS” indicates p-value ≥ 0.05. Besides the significant influence of the provider, housing laboratory, strain, diet, and gender on the gut bacterial genera, different effect sizes of these factors were also observed. Thus, “provider” markedly affects Bacteriodes and Alistipes to different degrees comparing G8 and G9; “strain” differentially affects Akkermansia in comparing G2, G3 and G4; and diet significantly affects Bacteriodes comparing G13, G14 and G15.