Supplementary Figure 5: Distribution of genes annotated against CAZy database in the mouse and human gut bacterial gene catalogue.

(a) Venn diagram of the CAZy families in human and mouse. A total of 304 enzyme families were annotated in the mouse catalogue and 301 of them are shared with human, further demonstrating the functional similarity between the mouse and the human gut microbiomes. (b) The distribution of genes annotated against the CAZy database. All the functional genes were divided into 6 enzyme classes/associated modules, CBM = carbohydrate-binding modules, CE = carbohydrate esterases, CL = cellulases, GH = glycoside hydrolases, GT = glycosyl transferases, PL = polysaccharide lyases. The distribution of the CAZy enzyme classes in the mouse gut bacterial gene catalogue is very similar to that of human gut bacterial catalogue reflecting the conservation of pathways involved in the breakdown, biosynthesis or modification of carbohydrates and glycoconjugates in the mouse and human gut microbiomes.