Supplementary Figure 2: Iterative development of Patch-seq procedures.

Step-wise improvements to the sampling, collection, ejection and analysis protocols are shown. Overall, 145 neurons were used to optimize recording and processing conditions, while ~120 neurons were processed to obtain reliable RNA-seq data. Axis labels on Bioanalyzer (Agilent) plots are: [FU], fluorescence unit; (bp) base pair. Magenta-colored “x” labels steps that had been omitted due to poorer outcomes.