Supplementary Figure 14: Noninvasive ctDNA detection and monitoring with iDES-enhanced CAPP-Seq (related to Fig. 5d).
From: Integrated digital error suppression for improved detection of circulating tumor DNA
To assess noninvasive ctDNA quantitation, monitoring using variants called from a tumor biopsy (‘Tumor’, blue line) was compared to monitoring using variants called directly from pretreatment cfDNA (‘cfDNA’, red line) from the same patient (using iDES). All 8 analyzed patients had a sequenced PBL sample and at least 3 longitudinal plasma time points available for correlation assessments. Open circles/squares indicate time points without significantly detectable ctDNA. ND, not detected. Time points are shown in chronological order (1st time point, pretreatment; later time points, post-treatment).
