Supplementary Figure 4: Second iteration of REVEALER for the transcriptional NRF2 activation in lung cancer example.
From: Characterizing genomic alterations in cancer by complementary functional associations
A) Conditioning to the summary feature after the first iteration, consisting of the seed feature (NFE2L2_MUT + NFE2L2_AMP) and KEAP1 mutations, REVEALER finds amplifications in chr15q22/26 (feature OR4F13P_AMP) as the top hit. B) The clustered version of the same top scoring features shown in A.
