Supplementary Figure 5: Assessment of the REVEALER features for the transcriptional NRF2 activation in lung cancer example in an independent test dataset.
From: Characterizing genomic alterations in cancer by complementary functional associations
The dataset is from The Cancer Genome Atlas (TCGA) consisting of 153 tumor samples (adenocarcinomas and squamous lung cancers). As can be seen in the figure the 4 features (NFE2L2_MUT, NFE2L2_AMP, KEAP1_MUT, and NOX5_AMP (15q23)) appear to generalize well to primary tumors and explain a significant number of samples with NRF2 activation in tumors.
