Figure 1: Manihot paleotetraploidy.

(a) Conserved synteny between five pairs of chromosomes and two sets of four chromosomes is shown. The ten chromosomes arranged in the large upper circle illustrate 1:1 synteny between five duplicated pairs of chromosomes. Chromosomes are numbered with large black text and physical positions (in Mb) are noted in small black text. The chromosomes depicted in the two smaller circles each share syntenic regions with two other chromosomes, owing to chromosomal rearrangements that occurred after the whole-genome duplication. Pericentromeric regions are shaded on each chromosome, and syntenic segments between chromosomes are connected by gray bands. (b) Phylogeny of euphorbs and timing of genome duplication, inferred by comparing homologous divergences within Manihot and Hevea with orthologous divergences between species. Diamonds indicate the divergence between paralogous sequences within Manihot (red) and Hevea (purple).