Supplementary Figure 9: Effects of CD45–SAP and irradiation on blood and thymus | Nature Biotechnology

Supplementary Figure 9: Effects of CD45–SAP and irradiation on blood and thymus

From: Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Supplementary Figure 9

(a) Relative levels of peripheral B-cells at various times post 3 mg/kg CD45-SAP or 5Gy TBI conditioning in non-transplanted C57BL/6 mice. Data represent mean ± SEM (n = 20 mice/group, n = 4 mice per time point, assayed individually). (b) Thymus mass of non-treated control, 3 mg/kg CD45-SAP or 5Gy TBI conditioned C57BL/6 mice harvested 3 days post-treatment. Data represents mean ± SD (n = 4 mice/group, assayed individually). Relative levels of (c) red blood cells (RBC), (d) hemoglobin, (e) hematocrit, and (f) platelets at various time points following 3 mg/kg CD45-SAP or 5Gy TBI conditioning in C57BL/6 mice. Data represent mean percentage relative to untreated control ± SEM (n = 20 mice/group, n = 4 mice per time point, assayed individually). * indicates p value <0.05; ** indicates p value <0.01; *** indicates p value <0.001; n.s. indicates not significant (p value >0.05). Statistics calculated using two-sided unpaired t test.

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