Supplementary Figure 2: Quantification of Htt RNA by RNA-seq. | Nature Biotechnology

Supplementary Figure 2: Quantification of Htt RNA by RNA-seq.

From: Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice

Supplementary Figure 2

WT: wild type mice; Q20: HET mice from HdhQ20line; Q50: HET mice from HdhQ50 line; Q80: HET mice from HdhQ80line; Q92: HET mice from HdhQ92 line; Q111: HET mice from HdhQ111 line; Q140: HET mice from CAG 140 KI line; Q175: HET mice from zQ175 line. Number symbols (#) denote significant differences of the Htt mRNA levels compared to WT controls. Asterisks (*) denote significant differences of the Htt mRNA levels compared to Q20. Percents (%) denote significant differences of the Htt mRNA levels compared to Q50. Plus (+) denote significant difference of the Htt mRNA levels compared to Q80. Carets (^) denote significant difference of the Htt mRNA levels compared to Q92 and Q111. Ampersands (&) denote significant difference of the Htt mRNA levels compared to Q140. Htt mRNA levels appeared inversely proportional to Q length but independently of age. Data are expressed as mean + S.E.M.. N of WTs per age=7-48, n of HETs per line per age=6-8. Note: At 6 and 10 months of age, HdhQ50 tissues were examined in a separated study from the one that assessed Q20, Q80, Q92, Q111, Q140 and Q175 HET tissues. Values from HETs animals were normalized to the values of the WT animals run concurrently.

Back to article page