Supplementary Figure 8: Clustering adverse events as a function of drug exposures to suggest candidate protective agents of lithium toxicity. | Nature Biotechnology

Supplementary Figure 8: Clustering adverse events as a function of drug exposures to suggest candidate protective agents of lithium toxicity.

From: Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data

Supplementary Figure 8

Comparative analysis of differential AE rates across patients on lithium, arbs, and lithium + arbs shows that the observed reporting rate of neurological AEs is lower than the expected rate in patients on a combination of lithium and arbs (Ω < 0, FDR Benjamini and Hochberg, p < 0.001).

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