Supplementary Figure 13: Examples of hypotheses that can be generated from a subset of the molecule covariance network analyses in this study.
From: Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling
Nearest neighbor molecule covariance networks from uncharacterized proteins containing more than four connected nodes were tested for GO term enrichment using a Fisher’s exact test with Benjamini–Hochberg FDR adjustment to account for multiple hypothesis testing. Networks containing four or fewer connected nodes were analyzed manually for functionally related molecules. Based on these MCNA results, biological hypotheses about the functions of the uncharacterized proteins shown were developed.
