Supplementary Figure 8: Growth characteristics of folA mutations in M9 minimal media. | Nature Biotechnology

Supplementary Figure 8: Growth characteristics of folA mutations in M9 minimal media.

From: Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

Supplementary Figure 8

While F153R appears to maintain normal growth characteristics, the growth rate of the F153W mutation is significantly slower under these conditions, suggesting that these two amino acid substitutions at the same site have very different effects on organismal fitness presumably due to different changes invoked in the stability/dynamics of this protein.

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