Figure 1: The four-billion-year-old lipid bilayer protects cells from invading RNAs. | Nature Biotechnology

Figure 1: The four-billion-year-old lipid bilayer protects cells from invading RNAs.

From: Overcoming cellular barriers for RNA therapeutics

Figure 1

Unlike small-molecule drugs that can slip across the lipid bilayer, with the exception of some single-stranded phosphorothioate ASOs that can productively enter cells, the vast majority of RNA-based therapeutics are too charged and/or too large to enter cells, and require a delivery agent.

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