Supplementary Figure 7: Individual marker genes of pluripotency, germ layer identity and brain patterning
From: Guided self-organization and cortical plate formation in human brain organoids
a. Screen shots of the IGV view of single gene tracks of markers of pluripotency, neuroectoderm and mesendoderm in spheroid and micropatterned enCORs (labeled uPatterned) at 20 days. b. Single gene tracks of markers of rostral-caudal and dorsal-ventral brain patterning in spheroid and enCORs at 60 days. Schematic of marker expression in the developing brain shown below. c. Heatmap of Spearman correlation coefficients of differentially expressed genes at 60 days in H9 spheroids and enCORs with the Allen BrainSpan transcriptome, sorted by anterior-posterior regional identity and four stages of development.
