Supplementary Figure 10: Gene copy number correlations correlate strongly with mRNA but not with protein profiles, explaining the difference in the derived functional gene-association networks. | Nature Biotechnology

Supplementary Figure 10: Gene copy number correlations correlate strongly with mRNA but not with protein profiles, explaining the difference in the derived functional gene-association networks.

From: Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities

Supplementary Figure 10

(a) Protein and mRNA profile Spearman’s correlation matrices of 32 members of the 26S proteasome multi-protein complex (Supplementary Table 13). Protein co-regulation identifies 107 associations across the members and the correlation matrix reflects the proteasome substructure. Co-regulation of mRNA profiles identifies 3 high confidence interactions across the proteasome members. (b) Gene copy number variations are strongly correlated with mRNA levels of proteasome members (median ρ = 0.55, right panel) but do not correlated with protein levels (median ρ = -0.01, left panel).

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