Supplementary Figure 6: Assessment of multi-protein complexes (MPCs) predicted via core-attachment algorithm. | Nature Biotechnology

Supplementary Figure 6: Assessment of multi-protein complexes (MPCs) predicted via core-attachment algorithm.

From: Global landscape of cell envelope protein complexes in Escherichia coli

Supplementary Figure 6

(a) Size distribution of the predicted MPCs. (b) Number of predicted complexes containing a CEP that overlap with an EcoCyc complex. Each MPC is binned according to the maximum overlap of the predicted complex with an EcoCyc complex. (c) Binary interactions tested by yeast two-hybrid (Y2H) and/or bacterial two-hybrid (B2H) assays (bridged by one or more intermediates in the protein complexes derived from AP/MS experiments. We show mapping of 88 binary PPIs (purple dotted edges) tested to 103 putative MPCs, where 26 PPIs bridged within 25 complexes, and 75 between 85 complexes.

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