Supplementary Figure 9: Multi-protein complex (MPC) conservation.
From: Global landscape of cell envelope protein complexes in Escherichia coli
(a) Phylogenetic tree (i) based on the comparison of the complete proteomes of 20 different bacteria that were closely related to E. coli. Evolutionary conservation of PPIs (ii) based on the co-occurrence of CEP (or those that are essential) orthologs across diverse bacterial species; bars scaled relative to actual species CEP counts; *p-value by Student's t-test. (b) Fraction of conserved subunits of the 540 predicted MPCs across diverse classes of bacteria, with orthologs of E. coli subunits of the sulfonate-sulfur utilization (black dashed line in the heatmap) complex (ID 107) shown as an example.
