Supplementary Figure 10: Comparison of abundance-matched SMRT vs. synthetic long read (SLR) sequencing coverage.
From: Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation
(a) Human Microbiome Project Mock Community B members in decreasing order of GC content in genome. The percentage of the reference positions covered by SLRs is consistently lower than the percentage covered by abundance-matched SMRT reads. (b) Coverage variation for alignments of abundance-matched SLR and SMRT reads. A significant number of bases in SLRs are aligned in the same regions, creating dramatic peaks in coverage. SMRT reads largely lack these peaks and have a more uniform coverage profile.
