Supplementary Figure 4: Infant gut microbiome contigs binned by sequence composition and methylation profiles.
From: Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation
(a) t-SNE map of 5-mer frequency features for contigs assembled from a mixture of two infant microbiome samples. Several clusters contain a mixture of species from the same genus. (b) t-SNE map of methylation features for the same contigs. (c) t-SNE map of the same contigs binned by both 5-mer frequency and methylation profiles (Online Methods), which resolve the contigs into mostly species-specific clusters. Kraken annotation relies on an existing reference database (Online Methods) and is therefore incomplete; contigs not generating a database hit are marked Unlabeled. Contigs <10kb are omitted.
