Supplementary Figure 8: Base editing specificity of ABE in Dmd knockout mice.
From: Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
Base editing frequencies at potential off-target sites identified by Cas-OFFinder were measured using targeted deep sequencing of genomic DNA isolated from muscles 8 weeks after injection of tsAAV: ABE. Mismatched nucleotides and the PAM sequence are shown in red and blue, respectively. OT; off-target site. Data are presented as mean ± s.e.m. (n = 3 animals).
