Supplementary Figure 5: No off-target mutations at candidate sites in Tyr mutant mice. | Nature Biotechnology

Supplementary Figure 5: No off-target mutations at candidate sites in Tyr mutant mice.

From: Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy

Supplementary Figure 5

Potential off-target sites with up to 3 mismatches, relative to the wild-type sequence, were identified using Cas-OFFinder. Substitution frequencies at these potential off-target sites were measured using targeted deep sequencing. PAM sequences and mismatched nucleotides are shown in blue and red, respectively. Data are presented as mean ± s.e.m. (n = 9 animals).

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