Supplementary Figure 2: Codon usage across different Cas9 variants
From: Optimized base editors enable efficient editing in cells, organoids and mice
a. Plots show frequency of codons across each of the 20 amino acids in different Cas9 variants. Green represents the most commonly used codon across all human genes. Red represents codons that are present in human genes less than 50% of the time that would be expected by chance. Grey represents codons that are neither the most frequent nor underrepresented. b. Percentage of favored, disfavored, and neutral codons across different Cas9 sequences.
